Potassium Hydroxide → HCID 86717842, compound

Participants

Reaction Steps

A mixture of methyl 2-(tert-butoxy)-2-[3-(3,4-dihydro-2H-1-benzopyran-6-yl)imidazo[1,2-a]pyridin-2-yl]acetate (25e) (31 mg, 0.079 mmol) and potassium hydroxide (18 mg, 0.37 mmol) in a mixture of ethanol (3 mL) and water (1 mL) was refluxed for 1 hour. The mixture was concentrated in vacuo. Water (1 mL) was added to the residue and the aqueous layer was extracted with ethyl acetate (5 mL). The aqueous layer was acidified with 1M hydrochloric acid until pH 7 and extracted with dichloromethane (2×5 mL). The organic layer was concentrated in vacuo to provide the desired acid (17 mg, 0.044 mmol, 56%) as a beige solid.

Provenance & Evidence