HCID 86717846, compound → HCID 86717845, compound

Participants

Reaction Steps

At room temperature, a solution of methyl (4-1-benzopyran-6-yl-3-methyl-2-oxo-2,3-dihydro-thiazol-5-yl)-hydroxy-acetate (33d) (84 mg, 0.25 mmol) and silver oxide (580 mg, 2.5 mmol) in dichloromethane (500 μL) and tert-butyl bromide (5 mL) was stirred for 8 hours. The mixture was then filtered and concentrated. The crude product was purified by flash chromatography on silica gel (dichloromethane/ethyl acetate 90/10) to afford the desired product (33e) as a white solid (29 mg, 0.073 mmol, 29%).

Provenance & Evidence