Tetrahydrofuran → HCID 70818320, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of compound ethyl 2-(4-bromo-5-chloro-2-methylthiophen-3-yl)-2-oxoacetate (44b) (340 mg, 1.09 mmol), tetrahydrofuran (7 mL) and ethanol (1.7 mL) was added sodium tetraborohydride (37.2 mg, 0.98 mmol) at 0° C. The mixture was stirred at 0° C. for 2 hours. The mixture was quenched with hydrochloric acid 1N and extracted with ethyl acetate twice. The organic extract was washed with brine twice, dried over sodium sulfate, filtered and concentrated in vacuo to afford the crude alcohol (44c) as a colorless oil (335 mg, 1.07 mmol, 98%).

Provenance & Evidence