HuagongsheHuagongshe Chemistry Print Report · For research reference only
Icosapent → (2S,3R)-methyl 3-((S)-2-((5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenamido)propanoyloxy)-2-(nicotinamido)butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Icosapent | HCID 446284 | — |
| Reactant | (2S,3R)-methyl 3-((S)-2-((4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenamido)propanoyloxy)-2-(nicotinamido)butanoate | HCID 58173182 | — |
| Product | (2S,3R)-methyl 3-((S)-2-((5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenamido)propanoyloxy)-2-(nicotinamido)butanoate | HCID 58173168 | — |
Reaction Steps
The same synthetic sequence outlined above for the preparation of (2S,3R)-methyl 3-((S)-2-((4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenamido)propanoyloxy)-2-(nicotinamido)butanoate was used, except that (5Z,8Z,11Z,14Z,17Z)-eicosa-5,8,11,14,17-pentaenoic acid (EPA) was used instead of DHA. MS calculated for C34H47N3O6: 593.35. found: [M+H]+ 594.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09238077B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-464b2a23057b4f0e9748eb56f7c83300 |
| Source note | uspto-grants-2016_01 |