Diisopropylethylamine → HCID 67452542, compound

Participants

Reaction Steps

To a solution of (2,2-Dimethyl-3-methylamino-propyl)-carbamic acid tert-butyl ester (compound PP) (1.05 g, 4.85 mmol) in CHCl3 (10 mL) at ambient temperature was added DIEA (0.84 mL, 4.85 mmol) followed by Cbz-OSu (1.21 g. 4.85 mmol), and the reaction mixture was stirred for 2 h. The reaction mixture then was diluted with CHCl3 (100 mL), and washed with water (2×50 mL) and brine (50 mL). The organic layer was separated and dried over Na2SO4. The removal of the solvents in vacuo yielded crude compound QQ in quantitative yield (1.78 g, 4.85 mmol) as a foamy solid. LC-MS [M+H] 351.6 (C19H30N2O4+H, calc: 351.2). Compound QQ was used directly in the next reaction without further purification.

Provenance & Evidence