Potassium Carbonate → HCID 90016629, compound

Participants

Reaction Conditions

Reaction Steps

6.5 g of 4-(3-dibutylaminopropoxyl)benzoyl chloride (V) (0.02 mol) is dissolved in 60 mL of n-hexane. 2.50 g of ammonium hydroxide (0.02 mol, 1 eq) and 2.76 g of potassium carbonate (0.02 mol, 1 eq) are added. The reaction mixture is heated to 50° C. and stirred for 3 hours. After the reaction the solid inorganic salt is filtered, washed with 2×5 mL of n-hexane and the filtrate is concentrated. The residue is purified by column chromatography (spheric silica; eluent: toluene:MTBE:methanol=5:4:1) to give 5.34 g of the title compound (VIa) (87%) as a yellowish solid.

Provenance & Evidence