Methanol → 2-Chloro-4-(1-ethoxyvinyl)-6-(methoxymethyl)pyrimidine

Participants

Reaction Steps

Methanol (1.06 g, 33.1 mmol) and sodium hydroxide (5 M (aq), 2.0 mL, 9.94 mmol) were added to a solution of (2-chloro-6-(1-ethoxyvinyl)pyrimidin-4-yl)methyl methanesulfonate (1.94 g, 6.63 mmol) in benzene (25 mL). Tetrabutylammonium hydrogen sulfate (0.225 g, 0.66 mmol) was added. The mixture was stirred vigorously at rt for 6 h. The phases were separated and the organic phase was filtered through a short silica plug which was washed with 10% MeOH in EtOAc (75 mL) and the solvent was evaporated. The residue was purified by preparative HPLC to give the title compound 0.287 g (19%).

Provenance & Evidence