Aniline → HCID 90016577, compound

Participants

Reaction Conditions

Reaction Steps

6.5 g of 4-(3-dibutylaminopropoxyl)benzoyl chloride (V) (0.02 mol) is dissolved in 60 mL of n-hexane. 1.86 g of aniline (0.02 mol, 1 eq) and 2.76 g of potassium carbonate (0.02 mol, 1 eq) are added. The reaction mixture is heated to 50° C. and stirred for 4 hours. After the reaction the solid inorganic salt is filtered, washed with 2×10 mL of n-hexane and the filtrate is concentrated. The residue is purified by column chromatography (spheric silica; eluent: toluene:MTBE:methanol=5:4:1) to give 6.50 g of the title compound (VIe) (85%) as a yellow solid.

Provenance & Evidence