Pyridine → HCID 89801871, compound

Participants

Reaction Steps

Add 1.25 g (6.1 mol) 3-chloro-4-methyl-6-phenyl pyridazine, 0.99 g (11.0 mol) cuprous cyanide and 20 mL pyridine into 50 mL pressure reaction tube, allow the mixture react for 24 hours at 130° C. then cool down and filtrate, and wash the cake three times with 50 mL ethyl acetate, and the organic phase is washed twice with 100 mL 1N HCl, following by drying with anhydrous sodium sulfate, and brown solid compound, crude product 2, is obtained after concentration, the crude product can be directly used in the next step reaction without further purification, MS: 196.0 (M+H+).

Provenance & Evidence