Sodium Hydroxide → HCID 56835965, compound

Participants

Reaction Steps

To ethyl 3-benzyl-3-(4-fluoro-3-(2-(1-methyl-1H-imidazole-4-sulfonamido)ethoxy)phenyl)azetidine-1-carboxylate (20.8 mg, 0.040 mmol) in tetrahydrofuran (1 ml) was added a 1M lithium aluminium hydride solution in tetrahydrofuran (0.121 ml, 0.121 mmol) and refluxed for 2 h. Cooled down to room temperature and 2N NaOH was slowly added and extracted twice with dichloromethane, washed with sodium bicarbonate and brine, dried over MgSO4, filtered, evaporated and purified by flash silica gel chromatography on 4 g SiO2-cartridge using 10% MeOH in dichloromethane affording 8.9 mg of the titled compound as a white solid.

Provenance & Evidence