HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-Aminomethyltetrahydropyran | HCID 2773210 | — |
| Reactant | 4-Fluoro-3-nitrobenzenesulfonamide | HCID 16782487 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-nitro-4-((tetrahydro-2H-pyran-4-yl)MethylaMino)benzenesulfonaMide | HCID 57474953 | — |
Reaction Steps
A mixture of 4-fluoro-3-nitrobenzenesulfonamide (2.18 g), 1-(tetrahydropyran-4-yl)methylamine (1.14 g), and triethylamine (1 g) in tetrahydrofuran (30 mL) were stirred overnight, neutralized with concentrated HCl and concentrated. The residue was suspended in ethyl acetate and the precipitates were collected, washed with water and dried to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09238649B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-e5ab47ed8a9543e58382cd01de3763f3 |
| Source note | uspto-grants-2016_01 |