Hydrochloric Acid → 1-(2-(3-Methoxy-4-(2-methyloxazol-5-yl)phenylamino)-6-((2,2,2-trifluoroethoxy)methyl)-pyrimidin-4-yl)ethanone

Participants

Reaction Conditions

Reaction Steps

4-(1-Ethoxyvinyl)-N-(3-methoxy-4-(2-methyloxazol-5-yl)phenyl)-6-((2,2,2-trifluoroethoxy)-methyl)pyrimidin-2-amine (70 mg, 0.15 mmol) was dissolved in dioxane (10 mL). Water (0.5 mL) and hydrochloric acid (conc., 0.038 mL, 0.45 mmol) were added. The mixture was heated at 50° C. for 10 min. Sodium bicarbonate (s, 0.5 g) was added and mixture was stirred. Brine (2 mL) was added. The mixture was extracted with EtAOc (×2). The organic phase was dried (sodium sulfate) and evaporated to give the title compound as a dry film 64 mg (97%).

Provenance & Evidence