反应详情

To a suspension of 7-chloro-5-methyl-2-(methylthio)[1,2,4]triazolo[1,5-a]pyrimidine (Intermediate 8, (0.2 g, 0.932 mmol)), in ethanol (10 mL), 4-aminophenylsulfur pentafluoride (MANCHESTER, 0.204 g, 0.932 mmol) was added and the mixture was stirred at room temperature until reaching completion. Anhydrous ammonia (0.133 mL, 0.932 mmol) was then added to the mixture and solvent was removed in vacuo. The crude mixture was purified by flash chromatography (Si, eluting with Hexane/EtOAc mixtures form 95:5 to 40:60%). Upon collection of the appropriate fractions, the title compound was obtained as a light yellow solid.

1. customwas removed in vacuo
2. customThe crude mixture was purified by flash chromatography (Si, eluting with Hexane/EtOAc mixtures form 95:5 to 40:60%)
3. customUpon collection of the appropriate fractions