反应详情

To a suspension of 7-chloro-5-methyl-2-(methylthio)[1,2,4]triazolo[1,5-a]pyrimidine (Intermediate 8 (0.3 g, 1.397 mmol)) in ethanol (5 mL), 4-amino-2-fluorobenzotrifluoride (ALFAAESAR, 0.25 g, 1.397 mmol) was added and the mixture was stirred at room temperature for 2 h. Anhydrous ammonia (0.2 mL, 1.397 mmol) was added and solvent was removed in vacuo. The residue was purified by flash chromatography (Si, eluting with Hexane/EtOAc mixtures form 95:5 to 40:60%) to yield the title compound as a white solid.

1. additionwas added
2. customsolvent was removed in vacuo
3. customThe residue was purified by flash chromatography (Si, eluting with Hexane/EtOAc mixtures form 95:5 to 40:60%)