反应详情

To a suspension of 7-chloro-5-methyl-2-(methylthio)[1,2,4]triazolo[1,5-a]pyrimidine (Intermediate 8 (0.2 g, 0.932 mmol) in ethanol (5 mL), 4-(trifluoromethyl)aniline (ALDRICH, 0.117 mL, 0.932 mmol) was added and the mixture was stirred at room temperature for 3 h. Anhydrous ammonia (0.133 mL, 0.932 mmol) was added and solvent was removed in vacuo. The residue was purified by flash chromatography (Si, eluting with Hexane/EtOAc mixtures form 95:5 to 40:60%) to yield the title compound as a white solid.

1. additionwas added
2. customsolvent was removed in vacuo
3. customThe residue was purified by flash chromatography (Si, eluting with Hexane/EtOAc mixtures form 95:5 to 40:60%)