Ethyl Acetoacetate → HCID 178429171, compound

Participants

Reaction Steps

To a well-stirred solution of 5-(trifluoromethyl)-4H-1,2,4-triazol-3-amine (1 g, 6.58 mmol) in 15-20 mL glacial acetic acid, was added ethyl acetoacetate (2.57 g or 2.5 mL, 19.77 mmol) and the reaction mixture was refluxed for 6-6.5 h. Reaction progress was monitored by TLC. After completion, the reaction mixture was brought to room temperature and the excess glacial acetic acid was evaporated in vacuo. The light pinkish white solid, thus obtained, was filtered off, washed with dichloromethane and dried to yield 0.750 g (52.3%) of the titled compound.

Provenance & Evidence