4-Chloroaniline → HCID 4909257, compound

HRID 591238Notes

Reaction equation

HRID 591238 reaction equation
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.Cl[C:10]1[N:15]2[N:16]=[C:17]([C:19]([F:22])([F:21])[F:20])[N:18]=[C:14]2[N:13]=[C:12]([CH3:23])[CH:11]=1>C(O)C>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:10]2[N:15]3[N:16]=[C:17]([C:19]([F:20])([F:22])[F:21])[N:18]=[C:14]3[N:13]=[C:12]([CH3:23])[CH:11]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 78124-ChloroanilineHCID 15001317-chloro-5-Methyl-2-(trifluoroMethyl)-[1,2,4]triazolo[1,5-a]pyriMidine

Product 1

HCID 4909257HCID 4909257, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-chloroaniline (0.355 g, 2.78 mmol) was added to a well-stirred absolute ethanol solution of 7-chloro-5-methyl-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine (0.547 g, 2.32 mmol, 15-20 mL). After stirring for 6-8 hours at room temperature, the desired product crystallized and was then filtered. Subsequent purification using column chromatography gave the final product in 66% yield.

Workup

  1. customthe desired product crystallized
  2. filtrationwas then filtered
  3. customSubsequent purification

Sources & evidence

ORD record
ord-e5d14a8d99054149a77c7b917982f541
Source dataset
uspto-grants-2016_01
Patent number
US09238653B2

Reaction notes

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