反应详情

To a suspension of Intermediate 18 (0.042 g, 0.199 mmol) in ethanol (5 mL), 4-aminophenylsulfur pentafluoride (MANCHESTER, 0.044 g, 0.199 mmol) was added and the mixture was stirred at room temperature overnight. Solvent was removed in vacuo and the crude mixture was purified by flash chromatography (Si, eluting with Hexane/EtOAc mixtures from 75:25 to 25:75%) to yield the title compound as a white solid.

1. additionwas added
2. customSolvent was removed in vacuo
3. customthe crude mixture was purified by flash chromatography (Si, eluting with Hexane/EtOAc mixtures from 75:25 to 25:75%)