4-(Trifluoromethyl)aniline → HCID 51347106, compound

HRID 591254Notes

Reaction equation

HRID 591254 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1.Cl[C:13]1[N:18]2[CH:19]=[CH:20][N:21]=[C:17]2[N:16]=[C:15]([CH3:22])[CH:14]=1>C(O)C>[CH3:22][C:15]1[CH:14]=[C:13]([NH:7][C:6]2[CH:8]=[CH:9][C:3]([C:2]([F:10])([F:11])[F:1])=[CH:4][CH:5]=2)[N:18]2[CH:19]=[CH:20][N:21]=[C:17]2[N:16]=1

Participants

4

Reactant 2

HCID 99644-(Trifluoromethyl)anilineHCID 151165185-Chloro-7-methylimidazo[1,2-a]pyrimidine

Product 1

HCID 51347106HCID 51347106, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-(trifluoromethyl)aniline (602 mg, 3.74 mmol) was added to the stirred solution of 5-chloro-7-methylimidazo[1,2-a]pyrimidine (522 mg, 3.12 mmol) in excess of absolute ethanol. The reaction mixture was heated intermittently to maintain homogeneity (clear) of the reaction mixture. After stirring overnight at room temperature, the excess ethanol was removed in vacuo and the resultant crude was purified using column chromatography. Yield 0.593 mg (65% yield).

Workup

  1. temperatureThe reaction mixture was heated intermittently
  2. temperatureto maintain homogeneity (clear) of the reaction mixture
  3. customthe excess ethanol was removed in vacuo
  4. customthe resultant crude was purified

Sources & evidence

ORD record
ord-853d00beb2d74784b15dcbe91768ee2b
Source dataset
uspto-grants-2016_01
Patent number
US09238653B2

Reaction notes

Loading…