HRID591274

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)N[C@@H](CCC(Cc1ccc(OCc2ccccc2)cc1)(C(=O)OCc1ccccc1)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C

HCID70977725

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)N[C@@H](CCC(Cc1ccc(O)cc1)(C(=O)O)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C

HCID70941175

未命名化合物

收率 100.5%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a solution of 1.07 g di-tert-butyl (5S)-2-[4-(benzyloxy)benzyl]-2-(benzyloxycarbonyl)-5-[(tert-butoxycarbonyl)amino]hexanedioate (1.52 mmol) in methanol (20 mL) was added a 10% palladium on carbon hydrogenation catalyst (100 mg) at room temperature. The suspension was stirred overnight at room temperature under an atmosphere of hydrogen. The catalyst was removed by filtration and all volatiles were removed in vacuo. The crude product (800 mg, quantitative yield) was used in the next step without further purification.

WORKUP

后处理

customThe catalyst was removed by filtration
customall volatiles were removed in vacuo

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-abbc217e71944dce9221118731a1c1be
来源数据集: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09238631B2
来源说明: uspto-grants-2016_01

反应 SMILES

C([O:8][C:9]1[CH:51]=[CH:50][C:12]([CH2:13][C:14]([C:40]([O:42]CC2C=CC=CC=2)=[O:41])([CH2:22][CH2:23][C@H:24]([NH:32][C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[C:28]([O:27][C:25](=[O:26])[C@@H:24]([NH:32][C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[CH2:23][CH2:22][C:14]([C:15]([O:17][C:18]([CH3:19])([CH3:20])[CH3:21])=[O:16])([CH2:13][C:12]1[CH:11]=[CH:10][C:9]([OH:8])=[CH:51][CH:50]=1)[C:40]([OH:42])=[O:41])([CH3:29])([CH3:30])[CH3:31]