HCID 70941355, compound → Di-tert-butyl (2R)-2-[(tert-butoxycarbonyl)amino]-5-(4-hydroxybenzyl)hexanedioate

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Reaction Steps

A solution of 237 mg (5R)-6-tert-butoxy-2-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)-amino]-2-(4-hydroxybenzyl)-6-oxohexanoic acid (0.45 mmol) and 94 mg 4-N,N-dimethylaminopyridine (0.77 mmol) in 1,4-dioxane (5 mL) was heated under reflux for 2 hours. The residue was purified by column chromatography on silica gel using an ethyl acetate/hexane gradient to give 141 mg of the title compound (65% yield).

Provenance & Evidence