反应详情

43 mg (0.07 mmol) of di-tert-butyl (4S)-4-(4-{trans-[3-(benzyloxy)cyclobutyl]oxy}benzyl)-N-(tert-butoxycarbonyl)-L-glutamate were dissolved in 10 mL of methanol and under argon atmosphere palladium (10% on charcoal) was added and the suspension hydrogenated overnight at room temperature. The reaction mixture was filtered, the solvent evaporated and the residue was chromatographed on silica gel using a hexane/ethyl acetate gradient, and the appropriate fractions were combined and concentrated.

1. additionwas added
2. customthe suspension hydrogenated overnight
3. customat room temperature
4. filtrationThe reaction mixture was filtered
5. customthe solvent evaporated
6. customthe residue was chromatographed on silica gel using a hexane/ethyl acetate gradient
7. concentrationconcentrated