Toluene → HCID 70941156, compound

Participants

Reaction Steps

Di-tert-butyl (4R)—N-(tert-butoxycarbonyl)-4-{[5-(3-fluoropropyl)pyridin-2-yl]methyl}-L-glutamate (68 mg, 0.13 mmol) was solved in 3 ml trifluoroacetic acid and stirred for 24 h. To the mixture was added toluene (10 ml) and the resulting solution was concentrated in vacuo. The crude product was purified by HPLC. The appropriate fractions were collected, the acetonitrile evaporated under reduced pressure and the remaining aqueous solution was lyophilized.

Provenance & Evidence