反应详情

To a solution of 350 mg di-tert-butyl (4R)—N-(tert-butoxycarbonyl)-4-{[5-(2-fluoroethoxy)pyridin-2-yl]methyl}-L-glutamate (0.68 mmol; see Example 17d) in dichloromethane (5 mL) was added 185 mg meta-chloro peroxybenzoic acid (70%), and the mixture was stirred for 1 h at room temperature. The mixture was extracted with aqueous sodium bicarbonate, followed by re-extraction of the aqueous layer with dichloromethane. The combined organic layers were concentrated in vacuo, and the residue was purified by preparative HPLC (Method D) to give 340 mg of the target compound (93% yield).

1. extractionThe mixture was extracted with aqueous sodium bicarbonate
2. extractionfollowed by re-extraction of the aqueous layer with dichloromethane
3. concentrationThe combined organic layers were concentrated in vacuo
4. customthe residue was purified by preparative HPLC (Method D)