HRID591313

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：CC(C)(C)OC(=O)N[C@@H](CCC(CCc1ccc(OCc2ccccc2)cc1)(C(=O)OCc1ccccc1)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C

HCID117812701

未命名化合物

PRODUCTS

产物

反应SMILES：CC(C)(C)OC(=O)N[C@@H](CCC(CCc1ccc(O)cc1)(C(=O)O)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C

HCID70977801

未命名化合物

收率 89%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

To a solution of 125 mg of 4-benzyl 1,4-di-tert-butyl (1S)-6-[4-(benzyloxy)phenyl]-1-[(tert-butoxycarbonyl)amino]hexane-1,4,4-tricarboxylate (0.18 mmol) in methanol (5 mL) was added 10% palladium on charcoal (15 mg) and the mixture was stirred under an atmosphere of hydrogen for 16 h at room temperature. The catalyst was removed by filtration, and the filtrate was evaporated to give the target compound (84 mg, 89% yield) which was used without further purification.

WORKUP

后处理

customThe catalyst was removed by filtration
customthe filtrate was evaporated

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-8538f890aec44cc3aba7c975a0b828c7
来源数据集: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US09238631B2
来源说明: uspto-grants-2016_01

反应SMILES

C([O:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][C:17]([C:46]([O:48][C:49]([CH3:52])([CH3:51])[CH3:50])=[O:47])([C:36]([O:38]CC2C=CC=CC=2)=[O:37])[CH2:18][CH2:19][C@H:20]([NH:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[C:24]([O:23][C:21](=[O:22])[C@@H:20]([NH:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])[CH2:19][CH2:18][C:17]([C:46]([O:48][C:49]([CH3:50])([CH3:51])[CH3:52])=[O:47])([CH2:16][CH2:15][C:12]1[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=1)[C:36]([OH:38])=[O:37])([CH3:25])([CH3:26])[CH3:27]