反应详情

Di-tert-butyl 4-[4-(benzyloxy)benzyl]-N-trityl-L-glutamate (499 mg, 0.72 mmol) were dissolved in methanol (20 ml). Palladium (10% on charcoal) (228 mg; 214 μmol) was added and the suspension was shaken under a hydrogen atmosphere for 12 h. The reaction mixture was filtered through a pad of celite, concentrated under reduced pressure and the residue was purified by silica gel column chromatography to yield 75 mg (28.7%) of the product.

1. filtrationThe reaction mixture was filtered through a pad of celite
2. concentrationconcentrated under reduced pressure
3. customthe residue was purified by silica gel column chromatography