4-benzyl 1,4-di-tert-butyl (1S,4S)-1-[(tert-butoxycarbonyl)amino]-5-(4-nitrophenyl)-pentane-1,4,4-tricarboxylate → (5S)-2-(4-aminobenzyl)-6-tert-butoxy-2-(tert-butoxycarbonyl)-5-[(tert-butoxycarbonyl)amino]-6-oxohexanoic acid

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Reaction Steps

4-benzyl 1,4-di-tert-butyl (1S,4S)-1-[(tert-butoxycarbonyl)amino]-5-(4-nitrophenyl)-pentane-1,4,4-tricarboxylate (1.04 g, 1.618 mmol) were dissolved in methanol (20 ml). Palladium (10% on charcoal) (52 mg) was added and the suspension was shaken under a hydrogen atmosphere for 12 h. The catalyst was filtered off, the residue was concentrated in vacuo, and the product was obtained as white foam (864 mg, quant.).

Provenance & Evidence