Triethylamine → HCID 71657232, compound

Participants

Reaction Steps

To a mixture of 6-fluoro-1-(piperidin-4-yl)indoline, prepared as in STEP 2 above (128 mg, 0.5 mmol) and 4-nitrophenyl(4-methylthiazol-2-yl)carbamate, prepared as in STEP 3 above (186 mg, 0.4 mmol, ca. 60% purity) in CH2Cl2 (3 mL) was added Et3N (0.28 mL, 2 mmol) at room temperature. The resulting mixture was stirred at room temperature for 3 h and was poured into EtOAc/H2O (20 mL/20 mL). The organic layer was dried (Na2SO4) and filtered. The solvent was removed by roto-evaporator and the resulting residue purified by silica gel chromatography using 40% EtOAc/hexane as the eluent to yield 4-(6-fluoroindolin-1-yl)-N-(4-methylthiazol-2-yl)piperidine-1-carboxamide as a white solid.

Provenance & Evidence