Diethyl Ether → Trifluoroacetic acid

Participants

Reaction Steps

To a solution of tert-butyl 2-(4-(6-fluoroindolin-1-yl)piperidine-1-carboxamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate (501 mg, 1.0 mmol) in CH2Cl2 (2 mL) was added TFA (1 mL) dropwise at room temperature. The resulting mixture was stirred at room temperature for 45 min and then Et2O (40 mL) was added. The resulting mixture was stirred vigorously for 20 min and the solid was filtered. The solid was washed with Et2O (2 mL×3) and dried to yield 4-(6-fluoroindolin-1-yl)-N-(4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)piperidine-1-carboxamide as a TFA salt.

Provenance & Evidence