Methanol → HCID 71657446, compound

Participants

Reaction Steps

To a solution of 4-(6-fluoroindolin-1-yl)-N-(4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)piperidine-1-carboxamide, prepared as in Example 19 above (51.6 mg, 0.1 mmol) in CH2Cl2 (2 mL) was added pyridine (0.5 mL) and then acetyl chloride (0.014 mL, 0.2 mmol, 2 equiv) at room temperature. The resulting mixture was stirred at room temperature for 15 min and then MeOH (1 mL) was added. The resulting mixture was continuously stirred for 15 min and concentrated. The resulting residue was purified by column using EtOAc as the eluent to yield N-(5-acetyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)-4-(6-fluoroindolin-1-yl)piperidine-1-carboxamide.

Provenance & Evidence