反应详情

1-(2-(3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-5-methyl-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-yl)ethanone (25 mg, 0.06 mmol) in dioxane (3 mL) and water (3 mL) was treated with sodium borohydride (8 mg, 0.22 mmol). The mixture was stirred at rt for 30 min. Acetic acid (0.5 mL) was added and the mixture was stirred for 25 min. The mixture was concentrated and the residue was purified by preparative HPLC to give the title compound as a dry film, 13 mg (48%).

1. stirringthe mixture was stirred for 25 min
2. concentrationThe mixture was concentrated
3. customthe residue was purified by preparative HPLC