反应详情

1-(2-(3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)phenylamino)-6-(1-(2,2,2-trifluoroethoxy)-ethyl)pyrimidin-4-yl)ethanone (90 mg, 0.20 mmol) was dissolved in ethanol (5 mL). Sodium borohydride (30.3 mg, 0.80 mmol) was added in portions. The mixture was stirred at rt for 10 min. Acetone (2 mL) was added and the mixture was stirred for 20 min. The mixture was filtered, the volatiles were removed in vacuum, and the residue was purified by preparative HPLC to yield the title compound consisting of four stereoisomers, 64 mg (71%).

1. stirringthe mixture was stirred for 20 min
2. filtrationThe mixture was filtered
3. customthe volatiles were removed in vacuum
4. customthe residue was purified by preparative HPLC