反应详情

Methyl 4-((3-methoxy-5-(trifluoromethyl)phenyl)sulfanyl)-3-oxobutanoate (810 mg) was added to Eaton's reagent (1994 μl) at room temperature for 2 h. The mixture was poured into water at room temperature and extracted with EtOAc. The organic layer was separated, washed successively with water and brine, dried over MgSO4 and concentrated in vacuo. The residue was subjected to silica gel column chromatography (EtOAc/hexane) to give methyl(6-methoxy-4-(trifluoromethyl)-1-benzothiophen-3-yl)acetate as a crude product (604 mg). The product was used to the next step without further purification.

1. extractionextracted with EtOAc
2. customThe organic layer was separated
3. washwashed successively with water and brine
4. dry with materialdried over MgSO4
5. concentrationconcentrated in vacuo