HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 591446Generated: October 31, 2026
Dimethylformamide → (7-Fluoro-6-hydroxy-4-methyl-1-benzothiophen-3-yl)acetic acid
https://huagongshe.com/reaction/591446
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium 2-methyl-2-propanethiolate | HCID 5147913 | — |
| Reactant | Methyl(7-fluoro-6-methoxy-4-methyl-1-benzothiophen-3-yl)acetate | HCID 121004334 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Water | HCID 962 | — |
| Product | (7-Fluoro-6-hydroxy-4-methyl-1-benzothiophen-3-yl)acetic acid | HCID 89767685 | 122.7% |
Reaction Steps
To a mixture of methyl(7-fluoro-6-methoxy-4-methyl-1-benzothiophen-3-yl)acetate (248.4 mg) and DMF (dry) (7.5 mL) was added sodium 2-methyl-2-propanethiolate (415 mg) at room temperature. The mixture was stirred at 160° C. for 20 min. After cooling, the mixture was diluted with water and 1N HCl and extracted with EtOAc. The organic layer was washed successively with water and brine, dried over MgSO4, and concentrated in vacuo to give the title compound (273 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09238639B2 |
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| Source dataset | uspto-grants-2016_01 |
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| ORD ID | ord-6e10a423cf2447e088542f84347477cd |
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| Source note | uspto-grants-2016_01 |
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