Hydrochloric Acid → (7-Fluoro-4-methyl-6-((2-methyl-6-(trifluoromethyl)pyridin-3-yl)methoxy)-1-benzothiophen-3-yl)acetic acid

Participants

Reaction Steps

To a mixture of methyl(7-fluoro-4-methyl-6-((2-methyl-6-(trifluoromethyl)pyridin-3-yl)methoxy)-1-benzothiophen-3-yl)acetate (159.8 mg), THF (dry) (2.0 mL) and MeOH (2.0 mL) was added 1N NaOH (1.122 mL) at room temperature. The mixture was stirred at room temperature for 2 h. The mixture was neutralized with 1N HCl and concentrated in vacuo. The precipitate was collected by filtration to give a solid. The solid was crystallized from EtOAc-hexane to give the title compound (134 mg).

Provenance & Evidence