HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 591464Generated: October 26, 2026
Sodium Hydroxide → (7-Chloro-6-hydroxy-1-benzofuran-3-yl)acetic acid
https://huagongshe.com/reaction/591464
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 8-Chloro-4-(chloromethyl)-7-hydroxy-2H-chromen-2-one | HCID 89767929 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | (7-Chloro-6-hydroxy-1-benzofuran-3-yl)acetic acid | HCID 89767735 | — |
Reaction Steps
A mixture of 1N NaOH (56.7 mL) and 8-chloro-4-(chloromethyl)-7-hydroxy-2H-chromen-2-one (2.78 g) was stirred at 100° C. for 1 h. After cooling, the reaction mixture was acidified with 6N HCl (10 mL). The precipitate was collected by filtration to give the title compound (1.65 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09238639B2 |
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| Source dataset | uspto-grants-2016_01 |
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| ORD ID | ord-9cb8e4a309144364acb0d39132346473 |
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| Source note | uspto-grants-2016_01 |
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