Methanol → (6-((2,4-Dichlorobenzyl)oxy)-1,1-dioxido-1-benzothiophen-3-yl)acetic acid

Participants

Reaction Conditions

Reaction Steps

To a mixture of ethyl(6-((2,4-dichlorobenzyl)oxy)-1,1-dioxido-1-benzothiophen-3-yl)acetate (8.00 g), THF (64 mL), MeOH (64 mL) and H2O (32 mL) was added lithium hydroxide hydrate (1.58 g) and the resulting mixture was stirred at 25° C. for 16 h. The solvent was removed under reduced pressure. The residue was suspended in water, and the mixture was acidified by 6N HCl. The resulting solid was collected by filtration, and dried under reduced pressure to give the title compound (4.00 g).

Provenance & Evidence