Ethyl 2-chloroacetoacetate → HCID 23560694, compound

Participants

Reaction Steps

To a solution of 2-methylpropanethioamide (1.51 g) in EtOH (40 mL) was added ethyl 2-chloroacetoacetate (2.409 g) at room temperature. The mixture was refluxed for 2 h. After cooling, the mixture was concentrated in vacuo. The residue was purified by silica gel column chromatography (NH, EtOAc/hexane) to give the title compound (2.42 g).

Provenance & Evidence