HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 89767712, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 118656069 | HCID 118656069 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 89767712 | HCID 89767712 | — |
Reaction Steps
To a mixture of 6-((2,2-dimethylpropanoyl)oxy)-3-(2-methoxy-2-oxoethyl)-1-benzothiophene-4-carboxylic acid (145 mg) and DMF (dry) (5 mL) were added dimethylamine hydrochloride (50.6 mg), TEA (0.115 mL) and HATU (236 mg) at room temperature. The mixture was stirred at room temperature for 4 h. The mixture was poured into water at room temperature and extracted with EtOAc. The organic layer was separated, washed successively with water and brine, dried over MgSO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane) to give the title compound (133 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09238639B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-b3db6e020b864670aee5c4512e96a60e |
| Source note | uspto-grants-2016_01 |