HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 591517Generated: October 31, 2026
Ethanol → Ethyl(6-vinyl-1-benzothiophen-3-yl)acetate
https://huagongshe.com/reaction/591517
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Ethyl(6-(((trifluoromethyl)sulfonyl)oxy)-1-benzothiophen-3-yl)acetate | HCID 57443344 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | Ethyl(6-vinyl-1-benzothiophen-3-yl)acetate | HCID 131734526 | — |
Reaction Steps
To a mixture of ethyl(6-(((trifluoromethyl)sulfonyl)oxy)-1-benzothiophen-3-yl)acetate (600 mg) and EtOH (10 mL) were added potassium vinyl(trifluoro) borate (240 mg), PdCl2(dppf) (119 mg) and TEA (0.454 mL) at room temperature, and the mixture was heated to 110° C. with microwave irradiation for 15 min. The mixture was poured into brine at room temperature and extracted with EtOAc. The organic layer was separated, washed with brine, and dried over MgSO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane) to give the title compound (320 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09238639B2 |
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| Source dataset | uspto-grants-2016_01 |
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| ORD ID | ord-dd7bf1db8b574898864e57273b719aa9 |
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| Source note | uspto-grants-2016_01 |
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