Dimethylformamide → HCID 118667047, compound

Participants

Reaction Steps

To a mixture of 2-((3S)-6-((2,4-dichlorobenzyl)oxy)-2,3-dihydro-1-benzofuran-3-yl)ethanethiol (30 mg), DIPEA (0.029 mL) and DMF (dry) (15 mL) was added ethyl 2-bromoacetate (21.15 mg). The mixture was stirred at room temperature under argon atmosphere overnight. The mixture was poured into water and extracted with EtOAc. The organic layer was separated, washed successively with water and brine, dried over MgSO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane) to give the title compound (25.0 mg).

Provenance & Evidence