Tetrahydrofuran → HCID 131734531, compound

Participants

Reaction Steps

To a mixture of methyl((3S)-6-hydroxy-2,3-dihydro-1-benzofuran-3-yl)acetate (10.4 g) and THF (20 mL) was added N-chlorosuccinimide (6.67 g). The mixture was stirred at room temperature overnight. The mixture was poured into water and extracted with EtOAc. The organic layer was separated, washed successively with water and brine, dried over MgSO4 and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane) to give the title compound (8.8 g).

Provenance & Evidence