Sodium Carbonate → HCID 118667048, compound

Participants

Reaction Conditions

Reaction Steps

To the mixture of methyl(5-bromo-6-((2,4-dichlorobenzyl)oxy)-1-benzofuran-3-yl)acetate (166 mg), aqueous 2M Na2CO3 (0.561 mL) and methylboronic acid (44.7 mg) in DME (3.7 mL) was added Pd(Ph3P)4 (43.2 mg). The mixture was stirred at 80° C. for 7 h. To the mixture was added methylboronic acid (44.8 mg) again. The mixture was stirred at 80° C. under nitrogen atmosphere over weekend. The mixture was diluted with water and extracted with EtOAc. The organic layer was washed with brine, dried over MgSO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane) to give the title compound (45.0 mg).

Provenance & Evidence