HCID 89768100, compound → HCID 89767941, compound

HRID 591541Notes

Reaction equation

HRID 591541 reaction equation
C([O:8][C:9]1[CH:21]=[CH:20][C:12]2[C:13]([C:16]([O:18][CH3:19])=[O:17])=[CH:14][O:15][C:11]=2[CH:10]=1)C1C=CC=CC=1>[Pd].CO>[OH:8][C:9]1[CH:21]=[CH:20][C:12]2[CH:13]([C:16]([O:18][CH3:19])=[O:17])[CH2:14][O:15][C:11]=2[CH:10]=1

Participants

4

Reactant 1

HCID 89768100HCID 89768100, compound

Product 1

HCID 89767941HCID 89767941, compoundYield 102.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a mixture of methyl 6-(benzyloxy)-1-benzofuran-3-carboxylate (10 g) and MeOH (200 mL) was added 10% Pd—C (2 g). The mixture was stirred under hydrogen atmosphere overnight. The catalyst was removed by filtration. The filtrate was concentrated in vacuo to give the title compound (7.08 g).

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationThe filtrate was concentrated in vacuo

Sources & evidence

ORD record
ord-68e75194a4544eb6812f21222fb6f7f2
Source dataset
uspto-grants-2016_01
Patent number
US09238639B2

Reaction notes

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