Methanesulfonic Acid → HCID 131734535, compound

Participants

Reaction Conditions

Reaction Steps

To methyl 4-((3-chloro-5-methoxyphenyl)sulfanyl)-3-oxopentanoate (1.86 g) was added methanesulfonic acid (5.98 mL) at 0° C. The mixture was stirred at 0° C. under nitrogen atmosphere for 15 min. The mixture was poured into water and extracted with EtOAc. The organic layer was washed with brine, dried over MgSO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane) to give the title compound (1.01 g).

Provenance & Evidence