Tributylphosphine → HCID 89768806, compound

Participants

Reaction Steps

To a mixture of tri-n-butylphosphine (0.415 mL), methyl(4-chloro-6-hydroxy-2-methyl-1-benzothiophen-3-yl)acetate (150 mg) and (1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanol (105 mg) in THF (4.0 mL) was added ADDP (419 mg) at room temperature. The mixture was stirred at room temperature under nitrogen atmosphere for 1 h. The mixture was concentrated. To the residue was added IPE and the precipitate was filtered off and the filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (NH, EtOAc/hexane) and silica gel column chromatography (EtOAc/hexane) to give the title compound (218 mg) as a colorless solid. The solid was crystallized from EtOAc-hexane.

Provenance & Evidence