Hydrochloric Acid → HCID 89768809, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of methyl(4-chloro-2-methyl-6-((1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methoxy)-1-benzothiophen-3-yl)acetate (184.5 mg), THF (dry) (2.0 mL) and MeOH (2.0 mL) was added 1N NaOH (1.28 mL). The mixture was stirred at room temperature for 2 h and at 50° C. for 1 h. The mixture was neutralized with 1N HCl. The generated precipitate was collected by filtration to give a colorless solid. The solid was crystallized from EtOAc-hexane to give the title compound (161 mg).

Provenance & Evidence