反应详情

To a stirred solution of 1-(2-(3-methoxy-4-(4-methoxy-1H-imidazol-1-yl)phenylamino)-6-((2,2,2-trifluoroethoxy)methyl)pyrimidin-4-yl)ethanone (0.1 g, 0.22 mmol) in ethanol (5 mL) sodium borohydride (0.034 g, 0.89 mmol) was added. The mixture was stirred at rt for 10 min. Acetone (2 mL) was added and mixture was stirred for 20 min. The mixture was filtered, the filtrate was concentrated in vacuum and the residue was purified by preparative HPLC to give the title compound as a dry film, 50 mg (50%).

1. stirringmixture was stirred for 20 min
2. filtrationThe mixture was filtered
3. concentrationthe filtrate was concentrated in vacuum
4. customthe residue was purified by preparative HPLC