Potassium Carbonate → N-(1-(4-formylphenyl)piperidin-4-yl)acetamide

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-acetamidopiperidine (2.5 g, 17.5 mmol) in DMF (10 mL) was added 4-fluorobenzaldehyde (2.2 g, 17.5 mmol) and K2CO3 (2.9 g, 21.2 mmol). The reaction was heated at 120° C. for 4 hours, diluted with H2O, and extracted with EtOAc. The organics were washed sequentially with H2O and brine, dried (Na2SO4), filtered, and concentrated in vacuo, to afford N-(1-(4-formylphenyl)piperidin-4-yl)acetamide (3.1 g, 92%).

Provenance & Evidence