HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → 4-(4-Acetyl-3,5-dimethylpiperazin-1-yl)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4-(3,5-Dimethylpiperazin-1-yl)benzaldehyde | HCID 86662020 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(4-Acetyl-3,5-dimethylpiperazin-1-yl)benzaldehyde | HCID 86662014 | 83.5% |
Reaction Steps
A solution of 4-(3,5-dimethylpiperazin-1-yl)benzaldehyde (1.0 g, 4.6 mmol.) in CH2Cl2 (15 mL) was cooled to 0° C. and treated with Et3N (0.64 mL, 4.6 mmol) followed by acetyl chloride (0.33 mL, 4.6 mmol). The reaction stirred for 30 minutes, then concentrated in vacuo. Purification by flash chromatography on silica gel, eluting with 0% to 50% EtOAc/CH2Cl2, afforded 4-(4-acetyl-3,5-dimethylpiperazin-1-yl)benzaldehyde (1.0 g, 83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09238640B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-8aab3bd97e3c4644856e4e4ab86b9e9c |
| Source note | uspto-grants-2016_01 |